1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester
1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester
CAS: 800401-64-3
Molecular Formula: C10H10N2O2
1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester - Names and Identifiers
1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester - Physico-chemical Properties
| Molecular Formula | C10H10N2O2 |
| Molar Mass | 190.2 |
| Density | 1.272±0.06 g/cm3(Predicted) |
| Boling Point | 371.8±22.0 °C(Predicted) |
| Flash Point | 178.675°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 13.21±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.628 |
1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester - Reference Information
| Application | Ethyl 1H-pyrrolo [3,2-C] pyridine-2-carboxylate is an important raw material in organic synthesis, the derivative thereof is a glycogen phosphorylase inhibitor, and can be used for preventing or treating diabetes, hypertension, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, atherosclerosis or tissue ischemia, and can be used as a cardioprotective agent. |
| preparation | using 2-methyl-3-nitropyridine and inexpensive sodium methoxide as raw materials, preparation of 2-methyl-3-nitropyridine, the same use of Reissert synthesis of compounds, and finally get the final product 1H-pyrrolo [3,2-C] pyridine-2-carboxylic acid ethyl ester. In the condensation reaction, the ether is changed to methyl tert-butyl ether, which improves the safety of the reaction. In the cyclization reaction, hydrogen-palladium carbon is used to reduce, the by-product is less, the post-treatment is simple, and the column chromatography purification is not needed, industrial production can be realized. Can also be α,β-epoxy ketones and pyrrolidone as raw materials, in tert-butoxide lithium promoted reaction, high regioselectivity and high stereoselectivity to construct the pyrrolo [3,2-b] pyridine skeleton. |
Last Update：2024-04-09 20:52:54
![1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, ethyl ester](http://res.chembk.com/assets/str/2d/8/80/800401-64-3.png)
Supplier List
Product Name: 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Visit Supplier Webpage Request for quotation
CAS: 800401-64-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 800401-64-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Visit Supplier Webpage Request for quotation
CAS: 800401-64-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 800401-64-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History